[{"accession_id":"EGAD00001015502","title":"The G2 gene expression signature and MYC overexpression are independent poor prognostic factors in childhood high-grade osteosarcoma","description":"Key objective\nAre the prognostic transcriptomic G1/G2 gene expression signature, MYC overexpression, and MYC amplification replicable stratifying biomarkers for future clinical trials in high-grade osteosarcoma? \nKnowledge gathered\nIn an unselected cohort, the G2 gene expression signature and MYC overexpression, but not MYC amplification, were independently associated with poor event-free and overall survival. \nRelevance \nTranscriptomic biomarkers may serve as stratifying factors that guide the management of patients with high-grade osteosarcoma. Current data underlines the importance of prospective validation of the G1/G2 signature and MYC overexpression in an international, multicenter, study.","dataset_types":["Transcriptome profiling by high-throughput sequencing"],"technologies":null,"num_samples":1,"access_type":"controlled","is_in_beacon":false,"is_released":true,"released_date":"2025-03-20T12:51:37+01:00","is_deprecated":false,"policy_accession_id":"EGAP00001001121"},
{"accession_id":"EGAD00001015503","title":"The G2 gene expression signature and MYC overexpression are independent poor prognostic factors in childhood high-grade osteosarcoma","description":"Key objective\nAre the prognostic transcriptomic G1/G2 gene expression signature, MYC overexpression, and MYC amplification replicable stratifying biomarkers for future clinical trials in high-grade osteosarcoma? \nKnowledge gathered\nIn an unselected cohort, the G2 gene expression signature and MYC overexpression, but not MYC amplification, were independently associated with poor event-free and overall survival. \nRelevance \nTranscriptomic biomarkers may serve as stratifying factors that guide the management of patients with high-grade osteosarcoma. Current data underlines the importance of prospective validation of the G1/G2 signature and MYC overexpression in an international, multicenter, study.","dataset_types":["Exome sequencing"],"technologies":null,"num_samples":1,"access_type":"controlled","is_in_beacon":false,"is_released":true,"released_date":"2025-03-20T12:54:32+01:00","is_deprecated":false,"policy_accession_id":"EGAP00001001121"}]